View AbstractThe present research paper on Spatiotemporal variation in infant mortality rate – a comparative analysis of central Asian and South Asian regions, reveals a significant variation in infant mortality rate because of various socio-economic and political reasons. Five countries of central Asia Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan, and Uzbekistan were selected; similarly six countries of South Asia i.e. India, Pakistan, Nepal, Bhutan, Bangladesh, and Sri Lanka were selected. The paper is based on a secondary source of data. Time series analysis of the last six decades (1950-2010) was used to analyze the trend of IMR. Data for the last three years i.e., 2016, 2017, and 2018 was used to analyze the annual pattern of IMR pattern. The analysis shows that Central Asian countries have a low IMR rate (25/1000) in comparison to south Asian countries (30.6). Among The south Asian Countries, Pakistan has highest IMR rate (50 /1000 in 2018) followed by India (38/1000) Bangladesh( 31/1000), Bhutan (30/1000), Nepal(27/1000) and Srilanka (8/1000) While as Turkmenistan from central Asia has highest IMR rate (33/1000 in 2018) followed by Tajikistan(31/1000), Kyrgyzstan (25/1000), Kazakhstan ( 19/1000) and Uzbekistan ( 17/1000). So there is a wide range of IMR within the countries as well as between these two regions. An attempt has been made to suggest a planning strategy for decreasing IMR in both the regions.